Lilith and Adam
According to some Jewish texts Lilith was the first woman God created from the same mud as Adam, but she was severely unimpressed with Adam and decided that she would rule him and even *gasp!* be on top during sex. Adam ran off crying to God saying "She won't do as she's told!" so God told her to stay in her place and follow Adam's orders because it was the woman's purpose to serve the man, to which she replied "Well, screw you then. I'm outta' here" and she left Paradise to party with the demons. God tried to get her to come back, but she refused and finally he had to make Eve.
She was a Babylonian goddess of sex and prostitution, and was know as the concubine of the gods. But though she had many many many lovers she was also quite cruel to them, and the less powerful ones ended up as her slaves or died.